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Key Takeaway: More is not always better when it comes to antioxidants

Previous study has found that RAS blockers can reduce proteinuria and tubulointerstitial fibrosis not only through their hemodynamic/antihypertensive effects but also through the inhibition of NF-B, MCP1 gene expression, and macrophage infiltration, thereby exerting anti-inflammatory/antifibrotic effects in the STZ-induced diabetic rat model (194)

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It also outlines stability and pH compatibility, so formulators can make evidence-based choices rather than relying on marketing claims

doi: 10.20517/2394-5079.2021.03 60